A4 precursor protein 770 fragment 6676742,4dinitrophenol dap 1 product result. There are 20 suppliers who sells dinitrophenol 2 4 on, mainly located in asia. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and. Dinitrophenols are a class of manufactured chemicals that do not occur naturally in the environment.
Some chemicals in this database contain more information than others due to the original reason this information was collected and how the compilation was accomplished. William stillwell, in an introduction to biological membranes second edition, 2016. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. When in a dry form, it is a high explosive and has an instantaneous explosion hazard. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry. A year or more ago, i was on an antidepressant regimen that made me gain a lot of weight. Pdf two deaths attributed to the use of 2,4dinitrophenol. Its primary function is to produce heat and make less efficient of energy. Incompatible with heavy metals and their compounds. Dnp present in water and soil as a pollutant does not easily evaporate to air. Dinitrophenol definition of dinitrophenol by medical.
This file is licensed under the creative commons attributionshare alike 4. Dnp was a chemical originally developed as a dye and to ignite dynamite. A weight loss agent with significant acute toxicity and risk of death. This page is regularly updated, to include the most recently available clinical trial evidence. Degradation of 4nitrophenol, 2chloro4nitrophenol, and. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. Dnp is a compound used in the early 1900s as a weight. Show this safety data sheet to the doctor in attendance. Dnp is used in developing photography, killing fungi, and as an industrial pesticide. The mechanism of uncoupling of oxidative phosphorylation.
Aleksander sobolewski via wikimedia commons you are free. Also incompatible with strong oxidizing agents, strong bases and. All structured data from the file and property namespaces is available under the creative commons cc0 license. The top countries of suppliers are india, china, from which the percentage of dinitrophenol 2 4 supply is 15%, 80% respectively.
Full text full text is available as a scanned copy of the original print version. Shindler1 1scheie eye institute and fm kirby center for molecular ophthalmology, university of pennsylvania, philadelphia, pa 19104, usa. After its inception, it was noticed in demographic statistics that employees who worked with dnp lost weight rapidly. Other applications include uses as an intermediate in dye processes and in smokeless gunpowders. Uses the predominant use of 2,4dinitrotoluene is as an intermediate in the manufacture of polyurethanes. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug. If inhaled if breathed in, move person into fresh air.
Like picric acid 2,4 6trinitrophenol, 2, 4dinitrophenol is a powerful explosive material. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. It is most often used as an antiseptic and a precursor to sulfur dyes. Sports medicinebodybuilding a potent nonselective inhibitor of oxidative phosphorylation, which results in increased metabolism and increased body temperature, and has been used illegally for weight control toxicology any of a family of compounds used in weed control and, at one time, for weight control, which may cause death. Strain rkj300 is capable of utilizing 4nitrophenol, 2chloro4nitrophenol, and 2,4dinitrophenol as sole sources of carbon and energy. Dnp is used to increase production of atp and enter body cells. Other pertinent literature is also presented, but is described in less detail than the key studies.
New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. The lowest published lethal human oral dose of dnp is 4. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. A bacterial strain rhodococcus imtechensis rkj300 mtcc 7085t jcm 270t was isolated from pesticidecontaminated soil of punjab by the enrichment technique on minimal medium containing 4nitrophenol. Fsa action over dnp fat burner substances august 21 20. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Links to pubmed are also available for selected references. Get a printable copy pdf file of the complete article 2. A wide variety of dinitrophenol 2 4 options are available to you, such as medicine grade, industrial grade, and food grade. It was synthesised in a multistep reaction, starting. Mitochondrial uncoupler prodrug of 2,4dinitrophenol, mp201, prevents neuronal damage and preserves vision in experimental optic neuritis reas s. The chemical structure of 2,4dinitrophenol is shown in figure 1. Explodes if dried and exposed to heat, flame, friction or shock.
The dissociation or uncoupling of phosphorylation from electron transport by 2,4dinitrophenol was first described by loomis and lipmann in 1948 1. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. This page was last edited on 12 february 2016, at 20. Metabolismo non sono disponibili informazioni sul metabolismo della molecola dnp. Mitochondrial uncoupler prodrug of 2,4dinitrophenol. The supplement dnp 2 4dinitrophenol is known for its high toxic but highly effective solution for person who wants to achieve a lot of weight loss. Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. It uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, leading to a. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. It is a yellow, crystalline solid that has a sweet, musty odor. The most commercially important dinitrophenol, 2,4 dinitrophenol dnp, is a yellow solid with no smell. Electronic spectrum of 2,4dinitrophenol in a 2 m solution of ammonia. The more the atp produced, the higher the metabolism which. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here.
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